This standard requires that fatigue life will be calculated considering all relevant cyclic loading imposed on the umbilical over its design life. ISO 13628-5 Subsea umbilicals is the main reference for design and load-effect analysis of umbilicals. Critical areas are normally at the floater interface where bend limiting devices, that is, a bend stiffener or a bellmouth, are applied to avoid overbending in extreme load situations and reduce long-term fatigue loading, see, for example, for further details. Fatigue analysis of helix elements such as tensile armors and steel tubes is a critical design issue for umbilicals and flexible pipes. The purpose of fatigue analysis is assessment of fatigue damage in all relevant elements in the cross-section for a long-term dynamic loading environment. The penalty is, however, that assessment of fatigue stresses in helix elements becomes complex due to the stick-slip behavior of helix elements in bending, as in Figure 1. This mechanism is essential for arranging flexible risers and umbilicals in compliant configurations that are capable of absorbing loads due to floater motions in harsh environmental conditions. The helix geometry allows the elements to slip in order to release axial stresses built up by cross-sectional bending. The required bending flexibility of risers and umbilicals is achieved by arranging strength and functional elements in a helix geometry. The performance of the described calculation scheme is illustrated by case studies. The described cross-sectional analysis techniques are based on an extensive literature survey and are hence considered to represent industry consensus. Special emphasis is placed on assessment of friction stresses caused by the stick-slip behavior of helix elements in bending that are of special importance for fatigue life assessments. The state of the different cross-section elements is based on the global response. The global cross-section is exposed to pure bending, tensile, torsion, and pressure loading. An overall computational consistent and efficient fatigue analysis scheme is outlined with due regard of the cross-sectional analysis technique required for fatigue stress calculation with particular attention to the helix elements. The long-term stress cycle distribution will hence require global dynamic time domain analysis followed by a detailed cross-sectional analysis in a large number of irregular sea states. The basis for assessment of fatigue damage of such elements is the long-term stress cycle distribution at critical locations on the helix elements caused by long-term environmental loading on the system. Fatigue analysis of structural components such as helix tensile armors and steel tubes is a critical design issue for dynamic umbilicals and flexible pipes.